Trifluoroacetic acid → HCID 44818367, compound

HRID 390063Notes

Reaction equation

HRID 390063 reaction equation
[Br:1][C:2]1[C:7]2[N:8]=[C:9](SC)[N:10]=[C:11]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=3)[C:6]=2[C:5](=[O:22])[NH:4][CH:3]=1.C1C=C(Cl)C=C(C(OO)=O)C=1.[NH2:34][CH2:35][CH2:36][CH2:37][NH:38]C(=O)OC(C)(C)C.C(O)(C(F)(F)F)=O>>[NH2:34][CH2:35][CH2:36][CH2:37][NH:38][C:9]1[N:10]=[C:11]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=2)[C:6]2[C:5](=[O:22])[NH:4][CH:3]=[C:2]([Br:1])[C:7]=2[N:8]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 58296328HCID 58296328, compoundHCID 86654203HCID 86654203, compound

Product 1

HCID 44818367HCID 44818367, compound

Procedure

The product was prepared from 8-bromo-4-[(3-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one using mCPBA/1,1-dimethylethyl (3-aminopropyl)carbamate and TFA sequences similar that described for Example 1 (Scheme 2). It was purified using reverse-phase HPLC.

Workup

  1. customIt was purified

Sources & evidence

ORD record
ord-d2090a4d61df45ccb80ad80a30ebaa36
Source dataset
uspto-grants-2013_02
Patent number
US08383635B2

Reaction notes

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