反应详情

2,4,6-Trimethyl-benzaldehyde (0.0005 mol) was added to a mixture of [6-(3-amino-phenoxy)-3-propyl-3,4-dihydro-quinazolin-2-yl]-carbamic acid tert-butyl ester (0.0005 mol) in DCE (3 mL) and the mixture was stirred for 5 min. at room temperature, and then NaBH(OAc)3 (0.0006 mol) was added and the reaction mixture was stirred overnight at room temperature. The excess NaBH(OAc)3 was decomposed with CH3OH, and the solvent was evaporated. The obtained residue was purified by Biotage column chromatography (eluent: 100% CH2Cl2). The purest product fractions were collected and then the solvent was evaporated and co-evaporated with toluene to yield the title compound as a residue.

1. stirringthe reaction mixture was stirred overnight at room temperature
2. customthe solvent was evaporated
3. customThe obtained residue was purified by Biotage column chromatography (eluent: 100% CH2Cl2)
4. customThe purest product fractions were collected
5. customthe solvent was evaporated