反应详情

To a solution of 4-hydroxybenzaldehyde (20 g, 163 mmol) in water (250 mL) is added Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione) (24.78 g, 171 mmol) as a slurry in water (250 mL) at 75° C. The reaction mixture is agitated for 2 hours, cooled in an ice bath, and extracted with EtOAc (2×400 mL). The combined extracts are washed with saturated brine, dried over sodium sulfate, filtered, and concentrated to a yellow solid (39 g, 97%). ESI/MS m/z 247.1 (M−H)−.

1. temperaturecooled in an ice bath
2. extractionextracted with EtOAc (2×400 mL)
3. washThe combined extracts are washed with saturated brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated to a yellow solid (39 g, 97%)