Potassium Cyanide → HCID 58066678, compound

HRID 390420Notes

Reaction equation

HRID 390420 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:15])[C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:5][C:4]=1[CH2:16][S:17][C:18]([CH3:21])([CH3:20])[CH3:19].[C-:22]#[N:23].[K+]>CS(C)=O>[C:18]([S:17][CH2:16][C:4]1[CH:5]=[C:6]([NH:9][C:10](=[O:15])[C:11]([CH3:14])([CH3:13])[CH3:12])[CH:7]=[CH:8][C:3]=1[CH2:2][C:22]#[N:23])([CH3:21])([CH3:20])[CH3:19]

Participants

4

Reactant 2

HCID 9032Potassium CyanideHCID 58066671HCID 58066671, compound

Product 1

HCID 58066678HCID 58066678, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

N-(4-Bromomethyl-3-tert-butylsulfanylmethyl-phenyl)-2,2-dimethyl-propionamide (1.8 g, 4.8 mmol) in DMSO (40 mL) was treated with potassium cyanide (0.325 g, 5.0 mmol), and the reaction was stirred for 1 hour at room temperature. The mixture was worked-up and purified by silica gel chromatography to give the title compound.

Workup

  1. custompurified by silica gel chromatography

Sources & evidence

ORD record
ord-8d0eb7a24e1945c1adeb85fb98b65fbe
Source dataset
uspto-grants-2013_02
Patent number
US08383654B2

Reaction notes

Loading…