Lithium Hydroxide → HCID 46208546, compound

HRID 390421Notes

Reaction equation

HRID 390421 reaction equation
C([O:3][C:4](=[O:31])[CH2:5][C:6]1[O:10][N:9]=[C:8]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:14][C:13]=2[CH2:25][S:26][C:27]([CH3:30])([CH3:29])[CH3:28])[N:7]=1)C.[Li+].[OH-]>CO.O>[C:27]([S:26][CH2:25][C:13]1[CH:14]=[C:15]([NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])[CH:16]=[CH:17][C:12]=1[CH2:11][C:8]1[N:7]=[C:6]([CH2:5][C:4]([OH:31])=[O:3])[O:10][N:9]=1)([CH3:30])([CH3:29])[CH3:28]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 58066673HCID 58066673, compound

Product 1

HCID 46208546HCID 46208546, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

{3-[2-tert-Butylsulfanylmethyl-4-(2,2-dimethyl-propionylamino)-benzyl]-[1,2,4]oxadiazol-5-yl}-acetic acid ethyl ester (0.28 mmol) in MeOH (5 mL) was treated with 1N aqueous LiOH (0.5 mL), and the reaction was stirred for 6 hours at room temperature. The mixture was diluted with H2O and extracted with EtOAc. The combined organic layers were dried and concentrated to give the title compound.

Workup

  1. extractionextracted with EtOAc
  2. customThe combined organic layers were dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-319f655f8c174b8d981706e5c428b382
Source dataset
uspto-grants-2013_02
Patent number
US08383654B2

Reaction notes

Loading…