反应详情

2.9 mL (2.9 mmol) of aqueous 1 M lithium hydroxide solution are added to a solution of 0.8 g (1.9 mmol) of ethyl (Z)-3-[3′-(3-butyl-1-methylureido)biphenyl-4-yl]-2-ethoxyacrylate in 10 mL of tetrahydrofuran. The reaction medium is heated at reflux for 20 hours. After cooling, 3 mL (2.9 mmol) of 1 N acetic acid are added and the reaction medium is extracted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution, filtered and evaporated. 760 mg (100%) of (Z)-3-[3′-(3-butyl-1-methylureido)biphenyl-4-yl]-2-ethoxyacrylic acid are obtained in the form of a white solid with a melting point of 126° C.

1. temperatureThe reaction medium is heated
2. temperatureat reflux for 20 hours
3. temperatureAfter cooling
4. extractionthe reaction medium is extracted with ethyl acetate
5. washThe organic phase is washed with saturated sodium chloride solution
6. filtrationfiltered
7. customevaporated