Hydrochloric Acid → HCID 86623518, compound

HRID 390892Notes

Reaction equation

HRID 390892 reaction equation
Cl.[Cl:2][C:3]1[N:4]=[C:5]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[C:6]2[S:11][C:10]([CH2:12][N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[C:9]([CH3:19])[C:7]=2[N:8]=1.[C:26](O)(=[O:29])[CH2:27][OH:28]>>[Cl:2][C:3]1[N:4]=[C:5]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[C:6]2[S:11][C:10]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:27](=[O:28])[CH2:26][OH:29])[CH2:15][CH2:14]3)=[C:9]([CH3:19])[C:7]=2[N:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 757Glycolic AcidHCID 866235192-Chloro-7-methyl-4-morpholino-6-((piperazin-1-yl)methyl)thieno[3,2-d]pyrimidine

Product 1

HCID 86623518HCID 86623518, compound

Procedure

The HCl salt of 2-chloro-7-methyl-4-morpholino-6-((piperazin-1-yl)methyl)thieno[3,2-d]pyrimidine (300 mg) was reacted with glycolic acid via General Procedure B to give 306 mg of 1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxyethanone.

Sources & evidence

ORD record
ord-8b4993cc48944544a51d9abe2039e7fb
Source dataset
uspto-grants-2013_02
Patent number
US08383620B2

Reaction notes

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