Hydrochloric Acid → HCID 43810645, compound

HRID 390986Notes

Reaction equation

HRID 390986 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.ClCCl.C(OCC)C>[ClH:24].[F:23][C:19]1[CH:18]=[C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:15])=[O:16])[CH:22]=[CH:21][CH:20]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 46180234HCID 46180234, compound

Product 1

HCID 43810645HCID 43810645, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(3-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (919 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (12 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(3-fluoro-benzenesulfonyl)-piperazine hydrochloride salt (807 mg).

Workup

  1. customVolatiles were removed in vacuo

Sources & evidence

ORD record
ord-5fc72b68a0b1475c90522c02cba78b30
Source dataset
uspto-grants-2013_02
Patent number
US08383620B2

Reaction notes

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