Trifluoroacetic acid → HCID 58233952, compound

HRID 391105Notes

Reaction equation

HRID 391105 reaction equation
C(O)(C(F)(F)F)=O.[CH3:8][NH:9][C:10]1[N:15]=[CH:14][C:13]([C:16]2[N:17]=[C:18]([N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[C:19]3[S:24][C:23]([CH2:25][N:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)=[C:22]([CH3:32])[C:20]=3[N:21]=2)=[CH:12][N:11]=1.[C:39](O)(=[O:43])[C@H:40]([CH3:42])[OH:41]>>[OH:41][C@@H:40]([CH3:42])[C:39]([N:29]1[CH2:30][CH2:31][N:26]([CH2:25][C:23]2[S:24][C:19]3[C:18]([N:33]4[CH2:34][CH2:35][O:36][CH2:37][CH2:38]4)=[N:17][C:16]([C:13]4[CH:14]=[N:15][C:10]([NH:9][CH3:8])=[N:11][CH:12]=4)=[N:21][C:20]=3[C:22]=2[CH3:32])[CH2:27][CH2:28]1)=[O:43]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 107689L-Lactic AcidHCID 66934178HCID 66934178, compound

Product 1

HCID 58233952HCID 58233952, compound

Procedure

The crude TFA salt of N-methyl-5-(7-methyl-4-morpholino-6-((piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine was reacted with L-lactic acid via General Procedure B to give 24.5 mg of 389 after reverse phase HPLC purification. MS (Q1) 513.3 (M)+.

Sources & evidence

ORD record
ord-817ee9eb642e4944aeba3f2a68c0ff8e
Source dataset
uspto-grants-2013_02
Patent number
US08383620B2

Reaction notes

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