Pyridine → HCID 67016587, compound

HRID 391158Notes

Reaction equation

HRID 391158 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1(C(F)(F)F)[CH2:8][C:7]([NH2:9])=[CH:6][CH:5]=[C:4]1[C:10]1[CH:16]=[CH:15][C:13](N)=[CH:12][CH:11]=1.[C:23]1(=[O:29])O[C:26](=[O:27])[CH:25]=[CH:24]1.N1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[C:36](OC(=O)C)(=O)C>O1CCCC1>[F:21][C:2]([F:22])([F:1])[C:3]1[CH:8]=[C:7]([N:9]2[C:26](=[O:27])[CH:25]=[CH:24][C:23]2=[O:29])[CH:6]=[CH:5][C:4]=1[C:10]1[CH:16]=[CH:15][CH:13]=[CH:12][C:11]=1[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

6

Reactant 4

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 7923Maleic AnhydrideHCID 86660908HCID 86660908, compound

Product 1

HCID 67016587HCID 67016587, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

Synthesis method: 2,2-bis(trifluoromethyl)benzidine was dissolved in tetrahydrofuran followed by the addition of maleic anhydride and allowing to react for 30 minutes while heating at 60° C. Subsequently, pyridine and acetic anhydride were added followed by additionally reacting for 1 hour. The solvent was removed from the resulting reaction solution with an evaporator and the resulting solid was recrystallized with acetic anhydride to obtain a pure product of 2-trifluoromethyl-4-maleimidophenyl biphenyl.

Workup

  1. customSynthesis method
  2. customto react for 30 minutes
  3. customThe solvent was removed from the resulting reaction solution with an evaporator
  4. customthe resulting solid was recrystallized with acetic anhydride

Sources & evidence

ORD record
ord-9219b409d28846fdb01d85aeac012bbf
Source dataset
uspto-grants-2013_02
Patent number
US08383742B2

Reaction notes

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