反应详情

温度

0 °C

To a solution of 6 chloro-7-aza indole (1.00 g, 6.55 mmol) in DMF (30 mL) at 0° C. was added sodium hydride (0.524 g, 13.11 mmol) and the mixture was stirred at 0° C. for 20 min. Methyl iodide (0.512 mL, 8.19 mmol) was added at 0° C. and the mixture was warmed to room temperature and stirred for 2 h. The reaction was stopped, quenched with water and extracted with ethyl acetate. The organic layer was washed with water. It was then dried over sodium sulfate and concentrated in vacuo to give 1.01 g of the desires product as a brown color oil. ESI-MS: m/z 167.0 (M+H)+

1. temperaturethe mixture was warmed to room temperature
2. stirringstirred for 2 h
3. customquenched with water
4. extractionextracted with ethyl acetate
5. washThe organic layer was washed with water
6. dry with materialIt was then dried over sodium sulfate
7. concentrationconcentrated in vacuo