Dichloromethane → 9-(Cyclohexylmethyl)-2-(3-hydroxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide

HRID 391688ノート

反応式

HRID 391688 の反応式
[NH2:1]/[C:2](/[C:17]#[N:18])=[C:3](\[NH:6][C:7]([NH:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:8])/[C:4]#[N:5].N/[C:20](=[C:23](\N)/C#N)/[C:21]#N.N(CC1CCCCC1)=C=[O:29].ClCCl.[O:40]1[CH2:44][CH2:43][CH2:42][CH2:41]1>>[CH:11]1([CH2:10][N:9]2[C:7](=[O:8])[NH:6][C:3]3[C:4]2=[N:5][C:41]([C:42]2[CH:23]=[CH:20][CH:21]=[C:44]([OH:40])[CH:43]=2)=[N:1][C:2]=3[C:17]([NH2:18])=[O:29])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

参加物

6

反応物 5

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 2723951DiaminomaleonitrileHCID 3414518(Isocyanatomethyl)cyclohexaneHCID 57474758(Z)-1-(2-Amino-1,2-dicyanovinyl)-3-(cyclohexylmethyl)urea

生成物 1

HCID 574747579-(Cyclohexylmethyl)-2-(3-hydroxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide収率 47%

実験手順

(Z)-1-(2-Amino-1,2-dicyanovinyl)-3-(cyclohexylmethyl)urea. 2,3-Diaminomaleonitrile (0.119 g, 1.10 mmol) and (isocyanatomethyl)cyclohexane (0.140 g, 1.00 mmol) in tetrahydrofuran (2 mL) were reacted according to General Procedure A. Dichloromethane and hexanes were added to the solution and the resultant precipitate was filtered and dried to afford the title compound (0.200 g, 47%). MS (ESI) m/z 248.2 [M+1]+.

後処理

  1. filtrationthe resultant precipitate was filtered
  2. customdried

出典と根拠

ORDレコード
ord-762ae629ad1342e6b1665755ac5b6dba
出典データセット
uspto-grants-2013_02
特許番号
US08383634B2

反応ノート

読み込み中…