反应详情

温度

80 °C

2.05 g (7.47 mmol) of the compound from Example 69A are dissolved in 70 ml of ethyl acetate and 70 ml of ethanol, 2.35 g (37.4 mmol) of ammonium formate and 0.39 g (0.37 mmol) of palladium/carbon (10%) are added and the mixture is stirred at 80° C. for 2 h. For work-up, the reaction solution is brought to room temperature and passed through a silica gel frit. The filter cake is washed with ethanol and the filtrate is concentrated under reduced pressure. The reaction product (1.65 g) is reacted without further purification.

1. customis brought to room temperature
2. washThe filter cake is washed with ethanol
3. concentrationthe filtrate is concentrated under reduced pressure
4. customThe reaction product (1.65 g) is reacted without further purification