Trifluoroacetic acid → HCID 22663050, compound

HRID 392134Notes

Reaction equation

HRID 392134 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9]([N:12]2[C:16]3=[CH:17][N:18]=[CH:19][CH:20]=[C:15]3[C:14]([CH2:21][CH2:22][NH:23]C(=O)OC(C)(C)C)=[CH:13]2)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9]([N:12]2[C:16]3=[CH:17][N:18]=[CH:19][CH:20]=[C:15]3[C:14]([CH2:21][CH2:22][NH2:23])=[CH:13]2)(=[O:10])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23521605HCID 23521605, compound

Product 1

HCID 22663050HCID 22663050, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of t-Butyl [2-{1-(3-methoxybenzenesulfonyl)-1H-pyrrolo[2,3-c]pyridin-3-yl}-ethyl]carbamate in CH2Cl2 is treated with trifluoroacetic acid, stirred for 2 h and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to afford the title-final product.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe resultant residue is purified by preparative reverse phase HPLC

Sources & evidence

ORD record
ord-6bb057a030fe4248a3edfb6b2f6ffaa3
Source dataset
uspto-grants-2004_10
Patent number
US06800640B2

Reaction notes

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