反应详情

A solution of methyl 1-triflyl-3-methyl-indazole-6-carboxylate (0.668 g, Reference Example 46) in a mixture of methanol and water (3:1, 80 ml) was treated with potassium carbonate (1.15 g). The mixture was heated at reflux for 5 hours then cooled to room temperature then poured into 1N hydrochloric acid (50 ml). The mixture was extracted three times with ethyl acetate (50 ml). The combined extracts were dried over sodium sulphate then evaporated. The residue was washed with a mixture of hexane and ether to give the title compound (0.360 g).

1. temperatureThe mixture was heated
2. temperatureat reflux for 5 hours
3. extractionThe mixture was extracted three times with ethyl acetate (50 ml)
4. dry with materialThe combined extracts were dried over sodium sulphate
5. customthen evaporated
6. washThe residue was washed with a mixture of hexane and ether