反应详情

温度

32.5 °C

In a mixture of 570 mL of 12 mol/L hydrochloric acid and 57 mL of tetrahydrofuran was suspended 57.3 g of 3,6-difluoro-2-pyrazinecarbonitrile. The suspension was stirred at 30-35° C. for 6.5 hours. The reaction mixture was concentrated to dryness under reduced pressure, 100 mL of ethanol was added, and then the solvent and hydrochloric acid were removed under reduced pressure. The residue thus obtained was washed with ethanol and diisopropyl ether to obtain 53.7 g of 3,6-difluoro-2-pyrazinecarboxamide as a colorless solid product.

1. concentrationThe reaction mixture was concentrated to dryness under reduced pressure, 100 mL of ethanol
2. additionwas added
3. customthe solvent and hydrochloric acid were removed under reduced pressure
4. customThe residue thus obtained
5. washwas washed with ethanol and diisopropyl ether