反应详情

In a mixture of 30 mL of acetonitrile and 15 mL of water was dissolved 1.0 g of 3-[4-(benzyloxy)phenoxy]-6-fluoro-2-pyrazinecarbonitrile. After adding 8.5 g of diammonium cerium nitrate, the mixture thus obtained was heated under reflux for 3 hours. The reaction mixture was returned to room temperature, a mixture consisting of 50 mL of ethyl acetate, 5 ml of water and 5 mL of 5% aqueous solution of sodium thiosulfate was added, and the organic layer was separated. The organic layer thus obtained was washed with saturated aqueous solution of sodium chloride, treated with active charcoal and dried on anhydrous magnesium sulfate, and then the solvent was removed under reduced pressure. Thus, 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarbonitrile was obtained as a yellow-colored solid product.

1. customthe mixture thus obtained
2. temperaturewas heated
3. temperatureunder reflux for 3 hours
4. customwas returned to room temperature
5. additionwas added
6. customthe organic layer was separated
7. customThe organic layer thus obtained
8. washwas washed with saturated aqueous solution of sodium chloride
9. additiontreated with active charcoal
10. dry with materialdried on anhydrous magnesium sulfate
11. customthe solvent was removed under reduced pressure