反应详情

温度

40 °C

In 10 mL of concentrated hydrochloric acid was dissolved 1.6 g of 6-fluoro-2-pyrazinecarbonitrile. The solution thus obtained was stirred at 40° C. for 2 hours. The reaction mixture was cooled to room temperature, a mixture of 25 mL of ethyl acetate and 10 mL of water was added, and the organic layer was separated. The aqueous layer was extracted with ethyl acetate. The organic layers were united, washed with saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=1:1] to obtain 0.75 g of 6-fluoro-2-pyrazinecarboxamide as a light brown-colored solid product.

1. customThe solution thus obtained
2. temperatureThe reaction mixture was cooled to room temperature
3. additionwas added
4. customthe organic layer was separated
5. extractionThe aqueous layer was extracted with ethyl acetate
6. washwashed with saturated aqueous solution of sodium chloride
7. dry with materialdried on anhydrous magnesium sulfate
8. customthe solvent was removed under reduced pressure
9. customThe residue thus obtained
10. customwas purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=1:1]