反应详情

温度

105 °C

In 39 mL of dimethyl sulfoxide was dissolved 1.95 g of 6-chloro-3-(4-methoxyphenoxy)-2-pyrazinecarbonitrile. After adding 2.16 g of potassium fluoride, the mixture thus obtained was stirred at 100-110° C. for 3 hours. The reaction mixture was returned to room temperature, a mixture of 40 mL of ethyl acetate and 200 mL of water was added, and the organic layer was separated. The organic layer thus obtained was washed with saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=5:1] to obtain 1.45 g of 6-fluoro-3-(4-methoxyphenoxy)-2-pyrazinecarbonitrile as a yellow-colored solid product.

1. customthe mixture thus obtained
2. customwas returned to room temperature
3. additionwas added
4. customthe organic layer was separated
5. customThe organic layer thus obtained
6. washwas washed with saturated aqueous solution of sodium chloride
7. dry with materialdried on anhydrous magnesium sulfate
8. customthe solvent was removed under reduced pressure
9. customThe residue thus obtained
10. customwas purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=5:1]