反应详情

Using the method of Example 342 using N-(3-bromophenyl)pyridin-3-ylmethylamine and guaiacol (Aldrich) and purifying via preparative HPLC eluting with 1:1 DCM/ethyl acetate gave N-(3-(2-Methoxyphenoxy)phenyl) pyrid-3-ylmethylamine. Anal Calcd for C19H18N2O2.0.5H2O: C, 72.36; H, 6.07; N, 8.88. Found: C, 72.43; H, 5.80; N, 8.96. MS found 307.2 [M+H]+

1. custompurifying via preparative HPLC
2. washeluting with 1:1 DCM/ethyl acetate