Ethanesulfonyl chloride → HCID 23521728, compound

HRID 392415Notes

Reaction equation

HRID 392415 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.[CH2:16]([S:18](Cl)(=[O:20])=[O:19])[CH3:17]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[S:18]([CH2:16][CH3:17])(=[O:20])=[O:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 7427744-bromo-N-(pyridin-3-ylmethyl)aniline

Product 1

HCID 23521728HCID 23521728, compound

Procedure

Using the procedure of Example 343 using N-(4-bromophenyl)pyridin-3-ylmethylamine and ethanesulfonyl chloride (Aldrich) and purifying via preparative HPLC eluting with 90:10 to 70:30 DCM/ethyl acetate gave the title compound. Anal Calcd for C14H15BrN2O2S: C, 47.33; H, 4.26; N, 7.88. Found: C, 47.24; H, 4.23; N, 7.79. MS found 354.0, 355.9 FD.

Workup

  1. custompurifying via preparative HPLC
  2. washeluting with 90:10 to 70:30 DCM/ethyl acetate

Sources & evidence

ORD record
ord-71b8add32e49412b82d877158351fa65
Source dataset
uspto-grants-2004_10
Patent number
US06800651B2

Reaction notes

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