2-Fluorophenol → HCID 69880868, compound

HRID 392416Notes

Reaction equation

HRID 392416 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[OH:23]>>[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 97072-FluorophenolHCID 7427744-bromo-N-(pyridin-3-ylmethyl)aniline

Product 1

HCID 69880868HCID 69880868, compound

Procedure

Using the method of Example 342 using N-(4-bromophenyl)pyridin-3-ylmethylamine and 2-fluorophenol (Aldrich)and purifying via preparative HPLC eluting with 90:10 to 80:20 DCM/ethyl acetate gave N-(4-(2-fluorophenoxy)phenyl)pyrid-3-ylmethylamine. Anal Calcd for C18H15FN2O: C, 73.45; H, 5.14; N, 9.52. Found: C, 73.36; H, 5.22; N, 9.35. MS found 295.1 [M+H]+

Workup

  1. custompurifying via preparative HPLC
  2. washeluting with 90:10 to 80:20 DCM/ethyl acetate

Sources & evidence

ORD record
ord-25cfcd47a3e3473093357d9d679fd19e
Source dataset
uspto-grants-2004_10
Patent number
US06800651B2

Reaction notes

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