HCID 18712878, compound → HCID 22662897, compound

HRID 392499Notes

Reaction equation

HRID 392499 reaction equation
C1([CH:7]([N:14]2[CH2:17][CH:16]([CH2:18][N:19]3[CH:23]=[CH:22][N:21]=[CH:20]3)[CH2:15]2)C2C=CC=CC=2)C=CC=CC=1>CCO.[OH-].[OH-].[Pd+2]>[N:19]1([CH2:18][CH:16]2[CH2:15][CH2:7][NH:14][CH2:17]2)[CH:23]=[CH:22][N:21]=[CH:20]1

Participants

4

Reactant 1

HCID 18712878HCID 18712878, compound

Product 1

HCID 22662897HCID 22662897, compoundYield 66.8%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

A mixture of the title compound(1.7 g) from Step D and Pd(OH)2 on carbon (0.2 g) in EtOH (20 mL) was stirred at 50 psi under an atmosphere of hydrogen for 24 h. The catalyst was filtered to give the title compound (0.508 g, 66.8%). m/z=137 (MH+)

Workup

  1. filtrationThe catalyst was filtered

Sources & evidence

ORD record
ord-16a2622ff0c34445ae12248849541ea1
Source dataset
uspto-grants-2004_10
Patent number
US06800636B2

Reaction notes

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