tert-Butyl 4-(1H-imidazol-1-yl)piperidine-1-carboxylate → 4-(1H-Imidazol-1-yl)piperidine

HRID 392502Notes

Reaction equation

HRID 392502 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[N:14]1([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:18]=[CH:17][N:16]=[CH:15]1

Participants

4

Reactant 1

HCID 22662911tert-Butyl 4-(1H-imidazol-1-yl)piperidine-1-carboxylate

Product 1

HCID 157899224-(1H-Imidazol-1-yl)piperidine

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The title compound(0.21 g, 0.836 mmoles) from Step C was stirred in 4N HCl in dioxane (5 mL) for 2 h and then evaporated to dryness to give the title compound which was used to couple with the tricylic acid.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-0afdb07d357e41c5bcf1446b96ce83bb
Source dataset
uspto-grants-2004_10
Patent number
US06800636B2

Reaction notes

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