Water → HCID 178508255, compound

HRID 393184Notes

Reaction equation

HRID 393184 reaction equation
[NH2:1][C:2]1[NH:7][C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:5][C:4](=[O:16])[C:3]=1[S:17][C:18]#[N:19].O>CN(C)C=O>[NH2:19][C:18]1[S:17][C:3]2[C:4](=[O:16])[N:5]=[C:6]([S:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[NH:7][C:2]=2[N:1]=1

Participants

4

Reactant 2

HCID 962WaterHCID 178514143HCID 178514143, compound

Product 1

HCID 178508255HCID 178508255, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product of step (a) (7.35 g) was heated at 120° C. in dimethylformamide (40 mL) and water (10 mL) for 10 hours. After cooling, the resulting solid was filtered off, washed with water, ether and ethyl acetate to give the title compound containing 0.4 moles of dimethylformamide.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resulting solid was filtered off
  3. washwashed with water, ether and ethyl acetate

Sources & evidence

ORD record
ord-1147a04203a9450d8f784dfb4bfdb789
Source dataset
uspto-grants-2004_10
Patent number
US06806273B1

Reaction notes

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