Tert-Butyl nitrite → HCID 178447700, compound

HRID 393185Notes

Reaction equation

HRID 393185 reaction equation
C[Si]([Br:5])(C)C.N(OC(C)(C)C)=O.N[C:14]1[S:15][C:16]2[C:21](=[O:22])[N:20]=[C:19]([S:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[NH:18][C:17]=2[N:29]=1>C(#N)C>[Br:5][C:14]1[S:15][C:16]2[C:21](=[O:22])[N:20]=[C:19]([S:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[NH:18][C:17]=2[N:29]=1

Participants

5

Reactant 3

HCID 10906Tert-Butyl nitriteHCID 76113BromotrimethylsilaneHCID 178447701HCID 178447701, compound

Product 1

HCID 178447700HCID 178447700, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Trimethylsilyl bromide (0.44 mL) was added slowly to a solution at 0° C. under nitrogen of us t-butyl nitrite (0.42 mL) in acetonitrile (2 mL). After 30 minute at 0° C., 2-amino-5-(pentylthio)thiazolo[4,5-d]pyrimidin-7(4H)-one (0.5 g) (product of Example 10) was added.

Sources & evidence

ORD record
ord-213296d7e40c43adb9c1fd56fb50261a
Source dataset
uspto-grants-2004_10
Patent number
US06806273B1

Reaction notes

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