反应详情

A solution 4-[4-(phenylmethoxy)phenyl]pyridine (120 mg, 0.46 mmol), Pd(OH)2/C (20% w/w, 10 mg) and aqueous 1.0 M HCl solution (0.5 mL) in MeOH (20 mL) was stirred under a hydrogen atmosphere (50 psi) for 17 h at 25° C. The catalyst was removed by filtration, Et3N (0.1 mL) was added and the filtrate was concentrated under reduced pressure. The residue was treated with hot THF. The resulting suspension was filtered and the filtrate concentrated under reduced pressure to give the title compound (69 mg, 88% yield) as a beige solid.

1. customThe catalyst was removed by filtration, Et3N (0.1 mL)
2. additionwas added
3. concentrationthe filtrate was concentrated under reduced pressure
4. additionThe residue was treated with hot THF
5. filtrationThe resulting suspension was filtered
6. concentrationthe filtrate concentrated under reduced pressure