反应详情

温度

35 °C

To a solution of 2-phenylethanesulfonamide (3.62 g) in methanesulfonic acid (20 ml)-acetic acid (5 ml) was added a solution of trioxane (582 mg) in trifluoroacetic acid (3 ml)and the mixture was stirred for 3 hours at 35° C. To the reaction mixture was added water and was extracted with chloroform. The organic layer was washed with water and a saturated aqueous solution of sodium bicarbonate, dried over anhydrous sodium sulfate and was concentrated. The residue was purified by column chromatography on silica gel (chloroform:methanol=100:1) to give the title compound (1.78 g) having the following physical data.

1. extractionwas extracted with chloroform
2. washThe organic layer was washed with water
3. dry with materiala saturated aqueous solution of sodium bicarbonate, dried over anhydrous sodium sulfate
4. concentrationwas concentrated
5. customThe residue was purified by column chromatography on silica gel (chloroform:methanol=100:1)