反应详情

4-Chloro-6,7-dimethoxyquinoline hydrochloride was dissolved in ethyl acetate, and the solution washed with a saturated solution of sodium hydrogen carbonate and then brine, dried (MgSO4) and the volatiles removed by evaporation. The crude product was purified by flash chromatography eluting with methylene chloride/acetonitrile (9/1 followed by 8/2) to give 4-chloro-6,7-dimethoxyquinoline (2.5 g, 80%) as a yellow solid.

1. washthe solution washed with a saturated solution of sodium hydrogen carbonate
2. dry with materialbrine, dried (MgSO4)
3. customthe volatiles removed by evaporation
4. customThe crude product was purified by flash chromatography
5. washeluting with methylene chloride/acetonitrile (9/1 followed by 8/2)