反应详情

温度

70 °C

4-Chloromethyl-2-methylthiazole hydrochloride (226 mg, 1.23 mmol) was added to a suspension of 4-chloro-7-hydroxy-6-methoxyquinoline (216 mg, 1 mmol), (prepared as described for the starting material in Example 3), and potassium carbonate (483 mg, 3.5 mmol) in DMF (10 ml). The mixture was stirred for 2.5 hours at 70° C. The volatiles were removed by evaporation and the residue was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried (MgSO4), the insoluble materials were removed by filtration and the volatiles were removed by evaporation. The residue was triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 4-chloro-6-methoxy-7-(2-methylthiazol-4-ylmethoxy)quinoline (352 mg, 55%).

1. custom(prepared
2. customThe volatiles were removed by evaporation
3. customthe residue was partitioned between ethyl acetate and water
4. washThe organic layer was washed with brine
5. dry with materialdried (MgSO4)
6. customthe insoluble materials were removed by filtration
7. customthe volatiles were removed by evaporation
8. customThe residue was triturated with ether
9. filtrationcollected by filtration
10. washwashed with ether
11. customdried under vacuum