1,1'-Carbonyldiimidazole → Oxazol-5-ylmethyl 1H-imidazole-1-carboxylate

HRID 39366Notes

Reaction equation

HRID 39366 reaction equation
[O:1]1[C:5]([CH2:6][OH:7])=[CH:4][N:3]=[CH:2]1.[C:8](N1C=CN=C1)([N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1)=[O:9]>C(Cl)Cl>[N:10]1([C:8]([O:7][CH2:6][C:5]2[O:1][CH:2]=[N:3][CH:4]=2)=[O:9])[CH:14]=[CH:13][N:12]=[CH:11]1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 187589851,3-Oxazol-5-ylmethanol

Product 1

HCID 57443694Oxazol-5-ylmethyl 1H-imidazole-1-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Oxazol-5-ylmethanol (0.15 g, 1.51 mmol) in anhydrous CH2Cl2 (5 mL) under a dry N2 atmosphere was treated with 1,1′-carbonyldiimidazole (0.20 g, 1.23 mmol) at ambient temperature and stirred for 2 hours to provide the title compound in a solution of CH2Cl2 which was used in subsequent Examples without further manipulation.

Sources & evidence

ORD record
ord-f1427693f0e24c61b207944f53e8ebc9
Source dataset
uspto-grants-2013_09
Patent number
US08524753B2

Reaction notes

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