Triethylamine → 3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[2-(4-nitrophenyl)ethyl]-benzamide

HRID 393839Notes

Reaction equation

HRID 393839 reaction equation
Cl.[N+:2]([C:5]1(OCC)[CH:10]=[CH:9][C:8](N)=[CH:7][CH2:6]1)([O-:4])=[O:3].[C:15]([C:19]1[CH:20]=[C:21]([CH:25]=[C:26]([C:29]([CH3:32])([CH3:31])[CH3:30])[C:27]=1[OH:28])[C:22]([OH:24])=O)([CH3:18])([CH3:17])[CH3:16].[CH2:33]([N:35](CC)CC)[CH3:34].C1(N=C=NC2CCCCC2)CCCCC1>C1COCC1>[CH3:30][C:29]([C:26]1[CH:25]=[C:21]([CH:20]=[C:19]([C:15]([CH3:17])([CH3:16])[CH3:18])[C:27]=1[OH:28])[C:22]([NH:35][CH2:33][CH2:34][C:8]1[CH:7]=[CH:6][C:5]([N+:2]([O-:4])=[O:3])=[CH:10][CH:9]=1)=[O:24])([CH3:31])[CH3:32]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 150073,5-Di-tert-butyl-4-hydroxybenzoic acidHCID 690034264-Nitrophenetylamine hydrochloride

Product 1

HCID 219186333,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[2-(4-nitrophenyl)ethyl]-benzamideYield 73%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.02 g (10 mmoles) of 4-nitrophenetylamine hydrochloride, 2.5 g (10 mmoles) of 3,5-di-tert-butyl-4-hydroxy-benzoic acid, 1.38 ml (10 mmoles) of triethylamine and 2.26 g (11 mmoles) of dicyclohexylcarbodiimide are introduced into a 100 ml flask containing 20 ml of THF. The reaction medium is agitated for 15 hours at ambient temperature, the precipitate which appears is filtered out and rinsed with ethyl acetate. After concentration of the filtrate under reduced pressure, the residue is precipitated from diethyl ether. The solid is recovered by filtration and rinsed with diethyl ether. A white powder is obtained with a yield of 73%. Melting point: 204-206° C.

Workup

  1. filtrationthe precipitate which appears is filtered out
  2. washrinsed with ethyl acetate
  3. customAfter concentration of the filtrate under reduced pressure, the residue is precipitated from diethyl ether
  4. filtrationThe solid is recovered by filtration
  5. washrinsed with diethyl ether
  6. customA white powder is obtained with a yield of 73%

Sources & evidence

ORD record
ord-4268dd7a01b24b658acdee4bacafc42d
Source dataset
uspto-grants-2004_10
Patent number
US06809088B2

Reaction notes

Loading…