Hydrochloric Acid → HCID 22648277, compound

HRID 393921Notes

Reaction equation

HRID 393921 reaction equation
[ClH:1].[CH2:2]([C:4]1[S:5][C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[C:8]([NH2:16])[C:7]=2[N:17]=1)[CH3:3]>C(O)(C)C>[ClH:1].[CH2:2]([C:4]1[S:5][C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[C:8]([NH2:16])[C:7]=2[N:17]=1)[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 99646202-Ethylthiazolo[4,5-c]quinolin-4-amine

Product 1

HCID 22648277HCID 22648277, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Concentrated hydrochloric acid (18.5 mmol) was added to a solution of 2-ethylthiazolo[4,5-c]quinolin-4-amine (4.25 g) in warm isopropanol. The reaction mixture was heated at reflux to reduce the volume and remove the water. The reaction mixture was cooled to ambient temperature. The precipitate was isolated by filtration and then dried to provide 2-ethylthiazolo[4,5-c]quinolin-4-amine hydrochloride as a solid, m.p. 268-270° C. Analysis: Calculated for C12H11N3S. HCl: % C, 54.23; % H, 4.55; % N, 15.81; Found: % C, 54.25; % H, 4.63; % N, 15.71.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux
  3. customremove the water
  4. customThe precipitate was isolated by filtration
  5. customdried

Sources & evidence

ORD record
ord-49a7b9fc23734f4e8184053f58debc5b
Source dataset
uspto-grants-2004_10
Patent number
US06809203B2

Reaction notes

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