Hydrochloric Acid → 3,3,3-Tris(4-vinylphenyl)propionic acid

HRID 394032Notes

Reaction equation

[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:23]2[CH:28]=[CH:27][C:26]([CH:29]=[CH2:30])=[CH:25][CH:24]=2)([C:15]2[CH:20]=[CH:19][C:18]([CH:21]=[CH2:22])=[CH:17][CH:16]=2)[CH2:10][C:11]([O:13]C)=[O:12])=[CH:5][CH:4]=1)=[CH2:2].[OH-].[Li+].Cl>O1CCOCC1>[CH:29]([C:26]1[CH:25]=[CH:24][C:23]([C:9]([C:6]2[CH:5]=[CH:4][C:3]([CH:1]=[CH2:2])=[CH:8][CH:7]=2)([C:15]2[CH:20]=[CH:19][C:18]([CH:21]=[CH2:22])=[CH:17][CH:16]=2)[CH2:10][C:11]([OH:13])=[O:12])=[CH:28][CH:27]=1)=[CH2:30]

Participants

Conditions

Temperature: 90 °C

Procedure

Fifty-four (54) mg of methyl 3,3,3-tris(4-vinylphenyl)propionate was suspended in 0.5 ml of dioxane, and to the suspension 0.5 ml of 4N aqueous lithium hydroxide solution was added at room temperature, followed by 17 hours' stirring at 90° C. under heating. The reaction liquid was made acidic by addition of 1N hydrochloric acid, extracted with chloroform and dried over anhydrous sodium sulfate. Distilling the solvent off under reduced pressure, 52.5 mg of the title compound was obtained.

Workup

temperatureunder heating
customThe reaction liquid
extractionextracted with chloroform
dry with materialdried over anhydrous sodium sulfate
distillationDistilling the solvent off under reduced pressure

Sources & evidence

ORD record: ord-5388572f11114103ab5bd965d59f8a24
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809108B1

Reaction notes

Loading…