反应详情

The title compound was prepared from HCl salt of 7-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-1-(2,6-dichlorophenyl)-5-(4-fluorophenyl)quinolin-2(1H)-one (EXAMPLE ABA11, Step A) by procedures analogous to that described in EXAMPLE HHH1, Step B, as a TFA salt. 1H NMR (CD3OD, 500 MHz) of TFA salt: δ 7.97 (d, J=9.8 Hz, 1H); 7.73 (m, 2H); 7.62 (m, 1H); 7.49 (m, 1H); 7.28 (m, 3H); 6.69 (d, J=9.8 Hz, 1H); 6.47 (s, 1H); 3.67 (m, 2H); 3.08 (m, 2H); 2.96 (m, 1H); 2.1 (m, 2H); 1.99 (m, 2H); 1.42 (s, 9H). Mass spectrum (ESI): 523.3 (M+1).