Trifluoroacetic acid → HCID 22648163, compound

HRID 394151Notes

Reaction equation

HRID 394151 reaction equation
C([O:5][CH2:6][CH:7]1[NH:12][CH2:11][CH2:10][N:9]([C:13]2[CH:22]=[C:21]3[C:16]([CH:17]=[CH:18][C:19](=[O:31])[N:20]3[C:23]3[C:28]([Cl:29])=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:30])=[C:15]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[Cl:38])[N:14]=2)[CH2:8]1)(C)(C)C.C(O)(C(F)(F)F)=O>>[Cl:38][C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=1[C:15]1[N:14]=[C:13]([N:9]2[CH2:10][CH2:11][NH:12][CH:7]([CH2:6][OH:5])[CH2:8]2)[CH:22]=[C:21]2[C:16]=1[CH:17]=[CH:18][C:19](=[O:31])[N:20]2[C:23]1[C:24]([Cl:30])=[CH:25][CH:26]=[CH:27][C:28]=1[Cl:29]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22647983HCID 22647983, compound

Product 1

HCID 22648163HCID 22648163, compound

Procedure

To 25 mg of 7-[3-(tert-butoxymethyl)piperazin-1-yl]-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one was added 1 mL of TFA. The mixture was stirred 2 h at rt, then concentrated. The residue was purified by preparative thin-layer chromatography, eluting with 9:1 CH2Cl2-2M NH3 in MeOH.

Workup

  1. concentrationconcentrated
  2. customThe residue was purified by preparative thin-layer chromatography
  3. washeluting with 9:1 CH2Cl2-2M NH3 in MeOH

Sources & evidence

ORD record
ord-c6c7aae89fc64656ba76dc1569735d51
Source dataset
uspto-grants-2004_10
Patent number
US06809199B2

Reaction notes

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