HRID394161

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

HCID18232

1-Piperidineethanol

C7H15NO

结构：CC1Cc2c(-c3ccccc3Cl)cc(O)cc2N(c2c(Cl)cccc2Cl)C1=O

HCID22648136

未命名化合物

PRODUCTS

生成物

结构：CC1Cc2c(-c3ccccc3Cl)cc(OCCN3CCCCC3)cc2N(c2c(Cl)cccc2Cl)C1=O

HCID22648201

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID220568

Diethyl azodicarboxylate

C6H10N2O4

PROCEDURE

实验过程

The title compound was prepared from 7 mg of 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-hydroxy-3-methyl-3,4-dihydroquinolin-2(1H)-one, 40 mg of Ph3P, 20 μL of 1-piperidine ethanol, and 20 μL of diethyl azodicarboxylate by a procedure analogous to that described in EXAMPLE 2. Mass spectrum (ESI) 545 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b7cea77af76b4ca9a84e58332ea799c1
来源数据集: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06809199B2
来源说明: uspto-grants-2004_10

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:17]=[C:16]([OH:18])[CH:15]=[C:14]2[C:9]=1[CH2:10][CH:11]([CH3:28])[C:12](=[O:27])[N:13]2[C:19]1[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=1[Cl:26].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[N:48]1([CH2:54][CH2:55]O)[CH2:53][CH2:52][CH2:51][CH2:50][CH2:49]1>N(C(OCC)=O)=NC(OCC)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:17]=[C:16]([O:18][CH2:55][CH2:54][N:48]2[CH2:53][CH2:52][CH2:51][CH2:50][CH2:49]2)[CH:15]=[C:14]2[C:9]=1[CH2:10][CH:11]([CH3:28])[C:12](=[O:27])[N:13]2[C:19]1[C:20]([Cl:26])=[CH:21][CH:22]=[CH:23][C:24]=1[Cl:25]