Tetrahydrothiophene → HCID 86584889, compound

HRID 394427Notes

Reaction equation

HRID 394427 reaction equation
[Br:1][CH2:2][C:3](=[O:6])[CH2:4][CH3:5].[S:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1>CC(C)=O>[Br-:1].[O:6]=[C:3]([CH2:4][CH3:5])[CH2:2][S+:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1

Participants

4

Reactant 2

HCID 1127TetrahydrothiopheneHCID 131561-Bromo-2-butanone

Product 1

HCID 86584889HCID 86584889, compoundYield 72.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In a 100 ml three-necked flask, 3.5 g of tetrahydrothiophene was dissolved in 40 ml of acetone. To the solution, 6 g of 1-bromo-2-butanone was added dropwise while stirring. After leaving for 24 hours, the deposited white crystal was collected by filtration. The white crystal was ground to a powder, which was washed with ether. The powder was dried by a vacuum drier at 30° C. for six hours to obtain 6.86 g of 2-oxobutyl-thiacyclopentanium bromide (yield: 72.2%).

Workup

  1. customAfter leaving for 24 hours
  2. filtrationthe deposited white crystal was collected by filtration
  3. washwas washed with ether
  4. customThe powder was dried by a vacuum drier at 30° C. for six hours

Sources & evidence

ORD record
ord-4dff82f26b7b473589abc5342e103442
Source dataset
uspto-grants-2003_08
Patent number
US06602647B2

Reaction notes

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