反应详情

Compound 8 (4.24 g, 9.66 mmol), 2,3-dichloro-5,6-dicyano-4-benzoquinone (4.38 g, 19.3 mmol), and acetonitrile (100 mL) were combined and stirred at room temperature under argon for 24 h. The solvent was removed in vacuo and 5% ammonium hydroxide was added. The solution was extracted exhaustively with methylene chloride. The combined organic extracts were dried over anhydrous sodium sulfate and the solvent was removed in vacuo to give a solid. Trituration with hexane-ether gave Compound 9 as a solid: 3.5 g (8.0 mmol, 82%)

1. customThe solvent was removed in vacuo and 5% ammonium hydroxide
2. additionwas added
3. extractionThe solution was extracted exhaustively with methylene chloride
4. dry with materialThe combined organic extracts were dried over anhydrous sodium sulfate
5. customthe solvent was removed in vacuo
6. customto give a solid