1,1-Dimethoxyethyl(dimethyl)amine → HCID 18176643, compound

HRID 394489Notes

Reaction equation

HRID 394489 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[O:6][CH2:7][CH2:8][CH2:9][CH2:10][S:11][C:12]1[N:17]=[N:16][C:15]([C:18](=[S:20])[NH2:19])=[CH:14][CH:13]=1.CO[C:28](OC)([N:30]([CH3:32])[CH3:31])[CH3:29]>C1(C)C=CC=CC=1>[CH3:31][N:30]([CH3:32])[C:28](=[N:19][C:18]([C:15]1[N:16]=[N:17][C:12]([S:11][CH2:10][CH2:9][CH2:8][CH2:7][O:6][C:5]2[CH:21]=[CH:22][CH:23]=[C:3]([C:2]([F:24])([F:1])[F:25])[CH:4]=2)=[CH:13][CH:14]=1)=[S:20])[CH3:29]

Participants

4

Reactant 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 181766426-[[4-[3-(Trifluoromethyl)-phenoxy]butyl]thio]-3-pyridazinecarbothioamide

Product 1

HCID 18176643HCID 18176643, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of intermediate 12 (0.009 mol) and N,N-dimethylacetamide dimethyl acetal (0.015 mol) in toluene (100 ml) was stirred and refluxed for 3 hours. The solvent was evaporated, yielding 4.1 g (100%) of N-[1-(dimethylamino)ethylidene]-6-[[4-[3-(trifluoromethyl)phenoxy]butyl]thio]-3-pyridazinecarbothioamide (intermediate 13).

Workup

  1. temperaturerefluxed for 3 hours
  2. customThe solvent was evaporated

Sources & evidence

ORD record
ord-ada604b38818417cae198d5f4227f8d7
Source dataset
uspto-grants-2003_08
Patent number
US06602873B2

Reaction notes

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