Triethylamine → HCID 13601222, compound

Temperature

-16 °C

A solution of 2.5 g (12.13 mmol) of the acid obtained in Step A in 30 ml of anhydrous tetrahydrofuran is cooled to −16° C.; 2.5 ml (18.2 mmol) of triethylamine are then added dropwise to the medium. After 10 minutes of stirring, 1.98 g (18.2 mmol) of ethyl chloroformate are slowly added to the reaction mixture. The solution is stirred under argon for 3 hours, the salts are filtered off and then the filtrate is cooled to −16° C. 1.84 g (48.5 mmol) of sodium borohydride are added to the medium all at once; 10 ml of methanol are then added very slowly to the solution. After 2 hours of stirring at −16° C., the reaction mixture is hydrolysed with a saturated solution of ammonium chloride; the aqueous phase is then extracted with ethyl acetate. The organic phase, dried over magnesium sulphate and then filtered, is concentrated under reduced pressure. The allyl alcohol of the title is obtained pure in the form of a yellow oil after passage over a silica column (eluant: AcOEt/PE: 30/70 then 50/50).

1. stirringThe solution is stirred under argon for 3 hours
2. filtrationthe salts are filtered off
3. stirringAfter 2 hours of stirring at −16° C.
4. extractionthe aqueous phase is then extracted with ethyl acetate
5. dry with materialThe organic phase, dried over magnesium sulphate
6. filtrationfiltered
7. concentrationis concentrated under reduced pressure

ORD record

ord-d8e899dd2f644ed4adc33660739f2e96

Source dataset

uspto-grants-2003_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06602903B2