反应详情

温度

20 °C

A suspension of 53.5 g of 4-hydroxy-6-methoxyquinoline-3-carboxylic acid in 1000 cm3 of diphenyl ether was heated with stirring, at a temperature of between 250° C. and 260° C., for 2 hours 45 minutes. The reaction mixture was cooled to about 20° C. After stirring for 16 hours at this temperature, the mixture was poured with stirring into 1 liter of pentane and then filtered. The cake obtained was washed with 3 times 100 cm3 of pentane and then with 3 times 100 cm3 of diisopropyl ether. After drying in air, 37 g of 4-hydroxy-6-methoxyquinoline were obtained in the form of a beige-colored solid.

1. temperaturewas heated
2. stirringAfter stirring for 16 hours at this temperature
3. additionthe mixture was poured
4. filtrationfiltered
5. customThe cake obtained
6. washwas washed with 3 times 100 cm3 of pentane
7. customAfter drying in air