Allylamine → HCID 4153372, compound

Temperature

15 °C

Hexanoyl chloride (33 g, 0.25 mol) in 250 mL of tetrahydrofuran was added to a three neck round bottom flask equipped with a thermometer, stir bar, and dropping funnel. The contents of the flask were then cooled to 15° C. in an ice bath while stirring. Allylamine (28.6 g 0.5 mol) in 200 mL of tetrahydrofuran was then added slowly through the dropping funnel while maintaining stirring. Throughout the addition, the temperature was maintained at 15° C. After addition was complete, stirring continued for an additional 15 minutes, after which the solid allylamine chloride precipitate was filtered off. The filtration was concentrated under vacuum to yield 37 g of N-allyl hexanamide as a colorless viscous liquid.

1. customequipped with a thermometer
2. stirringwhile stirring
3. temperaturewhile maintaining
4. stirringstirring
5. additionThroughout the addition
6. temperaturethe temperature was maintained at 15° C
7. additionAfter addition
8. stirringstirring
9. filtrationafter which the solid allylamine chloride precipitate was filtered off
10. filtrationThe filtration
11. concentrationwas concentrated under vacuum

ORD record

ord-d2ef61e5f5434733959ebae7490fc8d4

Source dataset

uspto-grants-2003_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06605270B1