反应详情

To a solution of 5-chloro-2-nitro-N-(2-pyridyl)benzamide (4 g, 14.4 mmol) in THF (50 mL) and ethyl acetate (50 mL) was added Raney nickel (0.5 g). The mixture was placed under an atmosphere of hydrogen (4.1 bar) overnight. The mixture was then filtered and the filtrate was flushed through a pad of silica gel, eluting with ethyl acetate, and then concentrated in vacuo. The crude solid was suspended in diethyl ether, sonicated, filtered and dried in vacuo to give 2.4 g (67%) of a faint green solid.

1. filtrationThe mixture was then filtered
2. customthe filtrate was flushed through a pad of silica gel
3. washeluting with ethyl acetate
4. concentrationconcentrated in vacuo
5. customsonicated
6. filtrationfiltered
7. customdried in vacuo