Triethylsilane → 1-(2-Iodoethyl)-4-octylbenzene

HRID 395943Notes

Reaction equation

HRID 395943 reaction equation
[I:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=O)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:6][CH:5]=1.C([SiH](CC)CC)C>FC(F)(F)C(O)=O>[CH2:10]([C:7]1[CH:6]=[CH:5][C:4]([CH2:3][CH2:2][I:1])=[CH:9][CH:8]=1)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Participants

4

Reactant 2

HCID 12052TriethylsilaneHCID 111320764'-(2-Iodoethyl)octanophenone

Product 1

HCID 105453621-(2-Iodoethyl)-4-octylbenzene

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

To a solution of 4′-(2-iodoethyl)octanophenone (200 g) in trifluoroacetic acid (319 ml) is added triethylsilane (195.7 ml) under ice-cooling, and the mixture is stirred at room temperature for 2 hr. The reaction mixture is concentrated, and the residue is distilled away under reduced pressure to give the title compound (7) as a pale-red oil. The resulting Compound (7) has the same physico-chemical characteristics as indicated in Example 15.

Workup

  1. temperaturecooling
  2. concentrationThe reaction mixture is concentrated
  3. distillationthe residue is distilled away under reduced pressure

Sources & evidence

ORD record
ord-100ce2bbc30a4158acd12bce979447fb
Source dataset
uspto-grants-2003_08
Patent number
US06605744B2

Reaction notes

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