反应详情

To a solution of t-butyl isothiocyanate (5.0 mL; 39.41 mmol) in CH2Cl2 (200 mL) was added cyclopentylamine (4.67 mL; 47.29 mmol) followed by DIEA and the reaction mixture was stirred at RT for 2 h. The mixture was diluted with EtOAc, washed with 10% citric acid (2×), saturated NaHCO3 (2×), H2O (2×) and brine (1×). The organic layer was dried over anhydrous MgSO4, filtered and evaporated to dryness to obtain the t-butyl-cyclopentylthiourea as a white solid (3.70 g; 47% yield).

1. washwashed with 10% citric acid (2×), saturated NaHCO3 (2×), H2O (2×) and brine (1×)
2. dry with materialThe organic layer was dried over anhydrous MgSO4
3. filtrationfiltered
4. customevaporated to dryness