反应详情

温度

100 °C

3-Bromoaniline (3.0 mL, 4.7 g, 28 mmol), 2-bromoethylether (4.2 mL, 7.7 g, 33 mmol) and diisopropylethylamine (15 mL, 11 g, 86 mmol) were dissolved in anhydrous DMF (20 mL) under inert gas atmosphere and heated to 100° C. for 6 h. After cooling to room temperature the mixture was poured into water (300 mL) and extracted with EtOAc. The combined organic layers were washed with brine, dried Na2SO4), filtered and evaporated to dryness. Purification of the residue by flash chromatography afforded 2.9 g (12 mmol, 43% yield) of 4-(3-bromophenyl)morpholine.

1. temperatureAfter cooling to room temperature the mixture
2. extractionextracted with EtOAc
3. washThe combined organic layers were washed with brine, dried Na2SO4),
4. filtrationfiltered
5. customevaporated to dryness
6. customPurification of the residue by flash chromatography