Trifluoroacetic acid → HCID 23004014, compound

HRID 396717Notes

Reaction equation

HRID 396717 reaction equation
C([N:8]1[C:16]2[C:11](=[CH:12][C:13]([CH:17]([CH3:24])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.FC(F)(F)C(O)=O>ClCCl>[NH:8]1[C:16]2[C:11](=[CH:12][C:13]([CH:17]([CH3:24])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23003959HCID 23003959, compound

Product 1

HCID 23004014HCID 23004014, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (R/S) ethyl 3-(1-boc-2,3-dihydro-1H-indol-5-yl)butyrate (3.1 g, Reference Example 6) in dichloromethane (30 ml), cooled in an ice bath, was treated with trifluoroacetic acid (30 ml). After about 30 minutes the reaction mixture was evaporated and traces of trifluoroacetic acid were removed by chasing off with toluene (twice), to give the title compound as a dark viscous gum, which was used immediately without further purification.

Workup

  1. customAfter about 30 minutes the reaction mixture was evaporated
  2. customtraces of trifluoroacetic acid were removed

Sources & evidence

ORD record
ord-e50a744408384583b5a810b9eb098f0f
Source dataset
uspto-grants-2003_08
Patent number
US06608084B1

Reaction notes

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