反应详情

4 portions of 4-chlorobutanoylchloride (0.32 ml×4) and triethylamine (0.3 g×4) were added in 24 hours to a solution of hydrocortisone (1 g) in CHCl3 dried over P2O5, and stirred for 3 days. The solution was treated with water, the organic phase was separated, dried (Na2SO4) and deprived of the solvent at reduced pressure. The crude residue was ground with hexane and CH2Cl2 to give a white solid with a 53% yield by weight, which had a melting point (m.p.) of 155° C.

1. dry with materialdried over P2O5
2. additionThe solution was treated with water
3. customthe organic phase was separated
4. dry with materialdried (Na2SO4)
5. customto give a white solid with a 53% yield by weight, which
6. customa melting point (m.p.) of 155° C.