Iodine → HCID 69364178, compound

HRID 397327Notes

Reaction equation

HRID 397327 reaction equation
[CH3:1][O:2][C:3](=[O:12])[NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[CH:6]=1.C([Li])(CC)C.[I:18]I>O1CCCC1>[CH3:1][O:2][C:3](=[O:12])[NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[I:18]

Participants

5

Reactant 3

HCID 807IodineHCID 3358980CARBAMIC ACID, (3-FLUOROPHENYL)-, METHYL ESTERHCID 178418400CID 53628100

Product 1

HCID 69364178HCID 69364178, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The starting material (3-fluoro-2-iodo-phenyl)-carbamic acid methyl ester was prepared from (3-fluoro-phenyl)-carbamic acid methyl ester by double deprotonation with sec.butyllithium in tetrahydrofuran at −78° C. followed by reaction with iodine. m.p.:80-82° C.

Sources & evidence

ORD record
ord-851486e0533a47ee84583327ef5d6ac7
Source dataset
uspto-grants-2003_08
Patent number
US06610685B2

Reaction notes

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